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Review
Chronic kidney disease (CKD) is a leading cause of end stage renal disease (ESRD) and cardiovascular morbidity and mortality worldwide, resulting in a growing social and economic burden. The prevalence and bur...
Inflammation and Regeneration 2017 37:17
Published on: 7 August 2017
Review
Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...
Inflammation and Regeneration 2017 37:10
Published on: 1 August 2017
Review
Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...
Inflammation and Regeneration 2017 37:13
Published on: 17 July 2017
Review
Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...
Inflammation and Regeneration 2017 37:11
Published on: 10 July 2017
Review
Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...
Inflammation and Regeneration 2017 37:16
Published on: 3 July 2017
Review
Skin fibrosis is a devastating clinical condition commonly seen in skin-restricted and systemic disorders. The goal of skin fibrosis treatment is the restoration of abnormally activated dermal fibroblasts prod...
Inflammation and Regeneration 2017 37:12
Published on: 12 June 2017
Review
Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. Extensive recent studies ha...
Inflammation and Regeneration 2017 37:14
Published on: 5 June 2017
Review
The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...
Inflammation and Regeneration 2017 37:15
Published on: 18 May 2017
Review
The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...
Inflammation and Regeneration 2017 37:9
Published on: 3 May 2017
Review
Dental pulp stem cells/progenitor cells (DPSCs) can be easily obtained and can have excellent proliferative and mineralization potentials. Therefore, many studies have investigated the isolation and bone forma...
Inflammation and Regeneration 2017 37:8
Published on: 10 April 2017
Review
The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...
Inflammation and Regeneration 2017 37:7
Published on: 3 April 2017
Review
Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to...
Inflammation and Regeneration 2017 37:6
Published on: 8 March 2017
Review
Colorectal cancer is the third most common cancer. Involvement of prostaglandin (PG) system in the pathogenesis of colorectal cancer has been suggested from clinical studies demonstrating therapeutic effect of...
Inflammation and Regeneration 2017 37:4
Published on: 1 March 2017
Research article
Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe ...
Inflammation and Regeneration 2017 37:5
Published on: 6 February 2017
Review
The inability to maintain the immaturity of stem cell populations in vitro restricts the long-term expansion of various types of human epithelial stem cells. However, recent technical advances in epithelial st...
Inflammation and Regeneration 2017 37:3
Published on: 6 February 2017
Research article
Pericytes, surrounding the endothelium, fulfill diverse functions that are crucial for vascular homeostasis. The loss of pericytes is associated with pathologies, such as diabetic retinopathy and Alzheimer’s d...
Inflammation and Regeneration 2017 37:2
Published on: 18 January 2017
Research article
Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...
Inflammation and Regeneration 2017 37:1
Published on: 16 January 2017
Review
Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...
Inflammation and Regeneration 2016 36:25
Published on: 5 December 2016
Research article
This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. MSCs show a unique function to modulate immune reaction although the molecular m...
Inflammation and Regeneration 2016 36:26
Published on: 17 November 2016
Review
Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...
Inflammation and Regeneration 2016 36:24
Published on: 15 November 2016
Review
Cardiovascular disease remains a major cause of death for which current therapeutic regimens are limited. Following myocardial injury, endogenous cardiac fibroblasts, which account for more than half of the ce...
Inflammation and Regeneration 2016 36:23
Published on: 24 October 2016
Review
The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the...
Inflammation and Regeneration 2016 36:19
Published on: 18 October 2016
Review
Traumatic spinal cord injury (SCI) causes irreparable severe motor and sensory dysfunction. Mechanical trauma rapidly leads to blood-spinal cord barrier disruption, neural cell death, axonal damage, and demyel...
Inflammation and Regeneration 2016 36:20
Published on: 17 October 2016
Editorial
Inflammation and Regeneration 2016 36:18
Published on: 5 October 2016
Review
The lungs are the primary organs for respiration, the process by which carbon dioxide and oxygen are exchanged. The alveolus, which is the site of gas exchange in the lungs, consists of multiple cell types inc...
Inflammation and Regeneration 2016 36:15
Published on: 12 September 2016
The official journal of the Japanese Society of Inflammation and Regeneration (JSIR)
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