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  1. Review

    Role of fibroblast growth factors in bone regeneration

    Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...

    Pornkawee Charoenlarp, Arun Kumar Rajendran and Sachiko Iseki

    Inflammation and Regeneration 2017 37:10

    Published on: 1 August 2017

  2. Review

    Pathophysiology and therapeutic potential of cardiac fibrosis

    Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...

    Hironori Hara, Norifumi Takeda and Issei Komuro

    Inflammation and Regeneration 2017 37:13

    Published on: 17 July 2017

  3. Review

    Regulation of blood vascular permeability in the skin

    Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...

    Sachiko Ono, Gyohei Egawa and Kenji Kabashima

    Inflammation and Regeneration 2017 37:11

    Published on: 10 July 2017

  4. Review

    Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases

    Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...

    Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata and Shuji Terai

    Inflammation and Regeneration 2017 37:16

    Published on: 3 July 2017

  5. Review

    Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells

    The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...

    Kenly Wuputra, Chang-Shen Lin, Ming-Ho Tsai, Chia-Chen Ku, Wen-Hsin Lin, Ya-Han Yang, Kung-Kai Kuo and Kazunari K. Yokoyama

    Inflammation and Regeneration 2017 37:15

    Published on: 18 May 2017

  6. Review

    Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

    The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...

    Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata and Junya Masumoto

    Inflammation and Regeneration 2017 37:9

    Published on: 3 May 2017

  7. Review

    Isolation of dental pulp stem cells with high osteogenic potential

    Dental pulp stem cells/progenitor cells (DPSCs) can be easily obtained and can have excellent proliferative and mineralization potentials. Therefore, many studies have investigated the isolation and bone forma...

    Takazumi Yasui, Yo Mabuchi, Satoru Morikawa, Katsuhiro Onizawa, Chihiro Akazawa, Taneaki Nakagawa, Hideyuki Okano and Yumi Matsuzaki

    Inflammation and Regeneration 2017 37:8

    Published on: 10 April 2017

  8. Review

    Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

    The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...

    Noriko Sugino, Tatsuo Ichinohe, Akifumi Takaori-Kondo, Taira Maekawa and Yasuo Miura

    Inflammation and Regeneration 2017 37:7

    Published on: 3 April 2017

  9. Review

    The roles of RGMa-neogenin signaling in inflammation and angiogenesis

    Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to...

    Yuki Fujita and Toshihide Yamashita

    Inflammation and Regeneration 2017 37:6

    Published on: 8 March 2017

  10. Research article

    Effect of human umbilical cord blood stem cell transplantation on oval cell response in 2-AAF/CCL4 liver injury model: experimental immunohistochemical study

    Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe ...

    Hussein Abdellatif, Gamal Shiha, Dalia M. Saleh, Huda Eltahry and Kamal G. Botros

    Inflammation and Regeneration 2017 37:5

    Published on: 6 February 2017

  11. Research article

    Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats

    Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...

    Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio and Ikuo Morita

    Inflammation and Regeneration 2017 37:1

    Published on: 16 January 2017

  12. Review

    Dissecting cellular senescence and SASP in Drosophila

    Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Takao Ito and Tatsushi Igaki

    Inflammation and Regeneration 2016 36:25

    Published on: 5 December 2016

  13. Review

    Organ dysfunction as a new standard for defining sepsis

    Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...

    Seitaro Fujishima

    Inflammation and Regeneration 2016 36:24

    Published on: 15 November 2016

  14. Review

    Liver regeneration and fibrosis after inflammation

    The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the...

    Minoru Tanaka and Atsushi Miyajima

    Inflammation and Regeneration 2016 36:19

    Published on: 18 October 2016

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