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  1. Research article

    Effects of CTLA4-Ig on human monocytes

    Abatacept, a CTLA4-Ig fusion protein attenuates T cell activation by inhibiting the CD80/86-CD28 costimulatory pathway that is required for the proper T cell activation and thus displays beneficial effects in ...

    Toshihiro Tono, Satoko Aihara, Takayuki Hoshiyama, Yoshiyuki Arinuma, Tatsuo Nagai and Shunsei Hirohata

    Inflammation and Regeneration 2017 37:24

    Published on: 6 November 2017

  2. Research article

    Characterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair

    We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However...

    Miki Maehara, Masato Sato, Eriko Toyoda, Takumi Takahashi, Eri Okada, Tomomi Kotoku and Masahiko Watanabe

    Inflammation and Regeneration 2017 37:22

    Published on: 1 November 2017

  3. Review

    Cell transfer technology for tissue engineering

    We recently developed novel cell transplantation method “cell transfer technology” utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patter...

    Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi and Ikuo Morita

    Inflammation and Regeneration 2017 37:21

    Published on: 16 October 2017

  4. Review

    The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis

    Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include t...

    Tadayoshi Karasawa and Masafumi Takahashi

    Inflammation and Regeneration 2017 37:18

    Published on: 11 September 2017

  5. Research article

    Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells

    In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MS...

    Aya Fujishiro, Yasuo Miura, Masaki Iwasa, Sumie Fujii, Noriko Sugino, Akira Andoh, Hideyo Hirai, Taira Maekawa and Tatsuo Ichinohe

    Inflammation and Regeneration 2017 37:19

    Published on: 1 September 2017

  6. Review

    Role of fibroblast growth factors in bone regeneration

    Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...

    Pornkawee Charoenlarp, Arun Kumar Rajendran and Sachiko Iseki

    Inflammation and Regeneration 2017 37:10

    Published on: 1 August 2017

  7. Review

    Pathophysiology and therapeutic potential of cardiac fibrosis

    Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...

    Hironori Hara, Norifumi Takeda and Issei Komuro

    Inflammation and Regeneration 2017 37:13

    Published on: 17 July 2017

  8. Review

    Regulation of blood vascular permeability in the skin

    Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...

    Sachiko Ono, Gyohei Egawa and Kenji Kabashima

    Inflammation and Regeneration 2017 37:11

    Published on: 10 July 2017

  9. Review

    Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases

    Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...

    Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata and Shuji Terai

    Inflammation and Regeneration 2017 37:16

    Published on: 3 July 2017

  10. Review

    Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells

    The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...

    Kenly Wuputra, Chang-Shen Lin, Ming-Ho Tsai, Chia-Chen Ku, Wen-Hsin Lin, Ya-Han Yang, Kung-Kai Kuo and Kazunari K. Yokoyama

    Inflammation and Regeneration 2017 37:15

    Published on: 18 May 2017

  11. Review

    Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

    The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...

    Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata and Junya Masumoto

    Inflammation and Regeneration 2017 37:9

    Published on: 3 May 2017

  12. Review

    Isolation of dental pulp stem cells with high osteogenic potential

    Dental pulp stem cells/progenitor cells (DPSCs) can be easily obtained and can have excellent proliferative and mineralization potentials. Therefore, many studies have investigated the isolation and bone forma...

    Takazumi Yasui, Yo Mabuchi, Satoru Morikawa, Katsuhiro Onizawa, Chihiro Akazawa, Taneaki Nakagawa, Hideyuki Okano and Yumi Matsuzaki

    Inflammation and Regeneration 2017 37:8

    Published on: 10 April 2017

  13. Review

    Pharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders

    The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...

    Noriko Sugino, Tatsuo Ichinohe, Akifumi Takaori-Kondo, Taira Maekawa and Yasuo Miura

    Inflammation and Regeneration 2017 37:7

    Published on: 3 April 2017

  14. Review

    The roles of RGMa-neogenin signaling in inflammation and angiogenesis

    Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to...

    Yuki Fujita and Toshihide Yamashita

    Inflammation and Regeneration 2017 37:6

    Published on: 8 March 2017

  15. Research article

    Effect of human umbilical cord blood stem cell transplantation on oval cell response in 2-AAF/CCL4 liver injury model: experimental immunohistochemical study

    Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe ...

    Hussein Abdellatif, Gamal Shiha, Dalia M. Saleh, Huda Eltahry and Kamal G. Botros

    Inflammation and Regeneration 2017 37:5

    Published on: 6 February 2017

  16. Research article

    Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats

    Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...

    Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio and Ikuo Morita

    Inflammation and Regeneration 2017 37:1

    Published on: 16 January 2017

  17. Review

    Dissecting cellular senescence and SASP in Drosophila

    Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Takao Ito and Tatsushi Igaki

    Inflammation and Regeneration 2016 36:25

    Published on: 5 December 2016

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