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  1. Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in...

    Authors: Lili Quan, Akiko Uyeda and Rieko Muramatsu
    Citation: Inflammation and Regeneration 2022 42:7
    Content type: Review Published on:

  2. The expression of FZD5 distinguishes immature human mesenchymal stem/stromal cells (MSC) in cultures, and the function of FZD5 is crucial for maintaining the proliferation and multilineage differentiation capacit...

    Authors: Satoru Miyagi, Yuko Kato, Ayako Watanabe, Kenichi Miyamoto, Rintaro Yoshikawa, Keita Hagiya, Daisuke Hirano and Yumi Matsuzaki
    Citation: Inflammation and Regeneration 2022 42:6
    Content type: Research article Published on:

  4. Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens. To suppress allo-immune respons...

    Authors: Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2022 42:4
    Content type: Research article Published on:

  5. ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO...

    Authors: Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa and Shuji Terai
    Citation: Inflammation and Regeneration 2022 42:3
    Content type: Research article Published on:

  6. Within the extensively developed therapeutic application of mesenchymal stem cells (MSCs), allogenic immunomodulatory therapy is among the promising categories. Although donor selection is a critical early pro...

    Authors: Yuta Imai, Kei Kanie and Ryuji Kato
    Citation: Inflammation and Regeneration 2022 42:8
    Content type: Research article Published on:

  7. The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of t...

    Authors: Yoshimitsu Nakanishi, Sujin Kang and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2022 42:5
    Content type: Review Published on:

  9. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investi...

    Authors: Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato and Takafumi Ichikawa
    Citation: Inflammation and Regeneration 2022 42:1
    Content type: Research article Published on:

  10. Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel...

    Authors: Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe and Fumiko Itoh
    Citation: Inflammation and Regeneration 2021 41:35
    Content type: Research article Published on:

  11. Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS ...

    Authors: Kenichi Serizawa, Haruna Tomizawa-Shinohara, Shota Miyake, Kenji Yogo and Yoshihiro Matsumoto
    Citation: Inflammation and Regeneration 2021 41:34
    Content type: Review Published on:

  12. The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan of more than 37 years and shows a negligible senescence phenotype, suggesting that tissue stem cells of NMRs are highly capable of m...

    Authors: Yuki Yamamura, Yoshimi Kawamura, Yuki Oiwa, Kaori Oka, Nobuyuki Onishi, Hideyuki Saya and Kyoko Miura
    Citation: Inflammation and Regeneration 2021 41:31
    Content type: Research article Published on:

  13. The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of vario...

    Authors: Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata and Naoe Kaneko
    Citation: Inflammation and Regeneration 2021 41:33
    Content type: Review Published on:

  14. Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in ...

    Authors: Masayuki Miyasaka
    Citation: Inflammation and Regeneration 2021 41:32
    Content type: Review Published on:

  16. The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated ...

    Authors: Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li…
    Citation: Inflammation and Regeneration 2021 41:28
    Content type: Research article Published on:

  18. The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-...

    Authors: Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe and Suguru Takeuchi
    Citation: Inflammation and Regeneration 2021 41:27
    Content type: Review Published on:

  20. The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vas...

    Authors: Ryota Hokari and Akira Tomioka
    Citation: Inflammation and Regeneration 2021 41:25
    Content type: Review Published on:

  23. Even within a single type of cancer, cells of various types exist and play interrelated roles. Each of the individual cells resides in a distinct microenvironment and behaves differently. Such heterogeneity is...

    Authors: Satoi Nagasawa, Yukie Kashima, Ayako Suzuki and Yutaka Suzuki
    Citation: Inflammation and Regeneration 2021 41:22
    Content type: Review Published on:

  24. Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel...

    Authors: Kentaro Iwata, Yohei Mikami, Motohiko Kato, Naohisa Yahagi and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:21
    Content type: Review Published on:

  26. Advances in DNA sequencing technology have significantly impacted human genetics; they have enabled the analysis of genetic causes of rare diseases, which are usually pathogenic variants in a single gene at th...

    Authors: Yusuke Kawashima, Ryuta Nishikomori and Osamu Ohara
    Citation: Inflammation and Regeneration 2021 41:19
    Content type: Review Published on:

  28. Systemic sclerosis (SSc) is a complex disease, in which an interaction of genetic and environmental factors plays an important role in its development and pathogenesis. A number of genetic studies, including c...

    Authors: Yuko Ota and Masataka Kuwana
    Citation: Inflammation and Regeneration 2021 41:17
    Content type: Review Published on:

  29. Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...

    Authors: Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono and Yoshiya Ito
    Citation: Inflammation and Regeneration 2021 41:16
    Content type: Review Published on:

  32. Silicone tube (ST) conduits have been accepted as a therapeutic alternative to direct nerve suturing in the treatment of nerve injuries; however, the search for optimal adjuncts to maximize the outcomes is sti...

    Authors: Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari and Alireza Shams
    Citation: Inflammation and Regeneration 2021 41:13
    Content type: Research article Published on:

  33. Extracellular vesicles (EVs) are known to be secreted by various cells. In particular, mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have tissue repair capacity and anti-inflammatory properties. Dental pul...

    Authors: Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara and Jun Takebe
    Citation: Inflammation and Regeneration 2021 41:12
    Content type: Research article Published on:

  34. The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and...

    Authors: Masahiro Nakano, Yukiko Iwasaki and Keishi Fujio
    Citation: Inflammation and Regeneration 2021 41:11
    Content type: Review Published on:

  39. To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...

    Authors: Yuya Shirai and Yukinori Okada
    Citation: Inflammation and Regeneration 2021 41:6
    Content type: Review Published on:

  40. Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and re...

    Authors: Azela Glady, Arno Vandebroek and Masato Yasui
    Citation: Inflammation and Regeneration 2021 41:4
    Content type: Research article Published on:

  41. Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...

    Authors: Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2021 41:5
    Content type: Review Published on:

  42. The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be genetic, but secondary to rapidly modernized environmen...

    Authors: Yusuke Yoshimatsu, Yohei Mikami and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:3
    Content type: Review Published on:

  44. Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiat...

    Authors: Erinn Zixuan Sim, Nobuaki Shiraki and Shoen Kume
    Citation: Inflammation and Regeneration 2021 41:1
    Content type: Review Published on:

  46. The world today is facing a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which mainly causes a respiratory disease known as coronavirus disease 2019 (COVID-19). Therefore, i...

    Authors: Taichiro Minami, Yasunori Iwata and Takashi Wada
    Citation: Inflammation and Regeneration 2020 40:31
    Content type: Review Published on:

    The Correction to this article has been published in Inflammation and Regeneration 2021 41:24

  47. Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of t...

    Authors: Kento Otani and Takashi Shichita
    Citation: Inflammation and Regeneration 2020 40:28
    Content type: Review Published on:

  48. Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunte...

    Authors: Sou Nakamura, Naoshi Sugimoto and Koji Eto
    Citation: Inflammation and Regeneration 2020 40:30
    Content type: Review Published on:

  49. The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are s...

    Authors: Arun Kumar Rajendan, Yoshinori Arisaka, Nobuhiko Yui and Sachiko Iseki
    Citation: Inflammation and Regeneration 2020 40:27
    Content type: Review Published on:


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Inflammation and Regeneration

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