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  1. To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...

    Authors: Yuya Shirai and Yukinori Okada
    Citation: Inflammation and Regeneration 2021 41:6
  2. Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and re...

    Authors: Azela Glady, Arno Vandebroek and Masato Yasui
    Citation: Inflammation and Regeneration 2021 41:4
  3. Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...

    Authors: Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2021 41:5
  4. The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be genetic, but secondary to rapidly modernized environmen...

    Authors: Yusuke Yoshimatsu, Yohei Mikami and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:3
  5. Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiat...

    Authors: Erinn Zixuan Sim, Nobuaki Shiraki and Shoen Kume
    Citation: Inflammation and Regeneration 2021 41:1
  6. The world today is facing a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which mainly causes a respiratory disease known as coronavirus disease 2019 (COVID-19). Therefore, i...

    Authors: Taichiro Minami, Yasunori Iwata and Takashi Wada
    Citation: Inflammation and Regeneration 2020 40:31

    The Correction to this article has been published in Inflammation and Regeneration 2021 41:24

  7. Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of t...

    Authors: Kento Otani and Takashi Shichita
    Citation: Inflammation and Regeneration 2020 40:28
  8. Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunte...

    Authors: Sou Nakamura, Naoshi Sugimoto and Koji Eto
    Citation: Inflammation and Regeneration 2020 40:30
  9. The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are s...

    Authors: Arun Kumar Rajendan, Yoshinori Arisaka, Nobuhiko Yui and Sachiko Iseki
    Citation: Inflammation and Regeneration 2020 40:27
  10. Bone homeostasis is dynamically regulated by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Visualizing and evaluating the dynamics of bone cells in vivo remain difficult u...

    Authors: Kunihiko Hashimoto, Takashi Kaito, Junichi Kikuta and Masaru Ishii
    Citation: Inflammation and Regeneration 2020 40:26
  11. Spinal cord injury (SCI) is a devastating event that causes permanent neurologic impairments. Cell transplantation therapy using neural precursor cells (NPCs) is a promising intervention aiming to replace dama...

    Authors: Narihito Nagoshi, Hideyuki Okano and Masaya Nakamura
    Citation: Inflammation and Regeneration 2020 40:40
  12. Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been ...

    Authors: Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi, Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2020 40:25
  13. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread globally to most countries. In Japan, the first COVID-...

    Authors: Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe and Hirotaka Kanuka
    Citation: Inflammation and Regeneration 2020 40:38
  14. In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world d...

    Authors: Misato Hashizume
    Citation: Inflammation and Regeneration 2020 40:24
  15. The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some...

    Authors: Shintaro Hojyo, Mona Uchida, Kumiko Tanaka, Rie Hasebe, Yuki Tanaka, Masaaki Murakami and Toshio Hirano
    Citation: Inflammation and Regeneration 2020 40:37
  16. Hair follicle (HF) formation and growth are sustained by epithelial-mesenchymal interaction via growth factors and cytokines. Pivotal roles of FGFs on HF regeneration and neogenesis have been reported mainly i...

    Authors: Misaki Kinoshita-Ise, Aki Tsukashima, Tomonari Kinoshita, Yoshimi Yamazaki and Manabu Ohyama
    Citation: Inflammation and Regeneration 2020 40:35
  17. In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are ...

    Authors: Kiyotaka Okada, Minoru Nishioka and Hiroshi Kaji
    Citation: Inflammation and Regeneration 2020 40:22
  18. The COVID-19 pandemic highlighted the vulnerability of every aspect of the globalized world, including R&D. Potentially critical R&D areas have been neglected because of the lack of market-driven incentives. H...

    Authors: Hiroki Nakatani, Kei Katsuno and Hayato Urabe
    Citation: Inflammation and Regeneration 2020 40:34
  19. Due to the nature of enhanced resistance to conventional chemo/radiotherapies and metastasis, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for cancer eradication. To tac...

    Authors: Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2020 40:33
  20. It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mech...

    Authors: Yoshitaka Kase and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:32
  21. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinica...

    Authors: Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2020 40:20
  22. Analysis of various genetically modified mice, with supernumerary teeth, has revealed the following two intrinsic molecular mechanisms that increase the number of teeth. One plausible explanation for supernume...

    Authors: Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata and Kazuhisa Bessho
    Citation: Inflammation and Regeneration 2020 40:21
  23. Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative ...

    Authors: So Nakagawa and Takayuki Miyazawa
    Citation: Inflammation and Regeneration 2020 40:17

    The Correction to this article has been published in Inflammation and Regeneration 2020 40:41

  24. An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating pandemic. As we have not developed curative medicine and effective vaccine, the end of this life-threatening infectious disease is...

    Authors: Ryo Otsuka and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2020 40:19
  25. Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.

    Authors: Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka and Masaru Ishii
    Citation: Inflammation and Regeneration 2020 40:15
  26. The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura…
    Citation: Inflammation and Regeneration 2020 40:14
  27. Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...

    Authors: Yoshitaka Kase, Takuya Shimazaki and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:10
  28. Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...

    Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada and Teruhisa Kawamura
    Citation: Inflammation and Regeneration 2020 40:8
  29. Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions i...

    Authors: Naoki Hosen
    Citation: Inflammation and Regeneration 2020 40:4
  30. Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signalin...

    Authors: Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki and Tomoki Nakashima
    Citation: Inflammation and Regeneration 2020 40:2
  31. Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...

    Authors: Yoshikazu Kishino, Jun Fujita, Shugo Tohyama, Marina Okada, Sho Tanosaki, Shota Someya and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2020 40:1
  32. Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...

    Authors: Yutaka Kuroda, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda
    Citation: Inflammation and Regeneration 2019 39:20


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