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  1. The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated ...

    Authors: Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li…
    Citation: Inflammation and Regeneration 2021 41:28
    Content type: Research article Published on:

  3. The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-...

    Authors: Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe and Suguru Takeuchi
    Citation: Inflammation and Regeneration 2021 41:27
    Content type: Review Published on:

  5. The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vas...

    Authors: Ryota Hokari and Akira Tomioka
    Citation: Inflammation and Regeneration 2021 41:25
    Content type: Review Published on:

  8. Even within a single type of cancer, cells of various types exist and play interrelated roles. Each of the individual cells resides in a distinct microenvironment and behaves differently. Such heterogeneity is...

    Authors: Satoi Nagasawa, Yukie Kashima, Ayako Suzuki and Yutaka Suzuki
    Citation: Inflammation and Regeneration 2021 41:22
    Content type: Review Published on:

  9. Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel...

    Authors: Kentaro Iwata, Yohei Mikami, Motohiko Kato, Naohisa Yahagi and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:21
    Content type: Review Published on:

  11. Advances in DNA sequencing technology have significantly impacted human genetics; they have enabled the analysis of genetic causes of rare diseases, which are usually pathogenic variants in a single gene at th...

    Authors: Yusuke Kawashima, Ryuta Nishikomori and Osamu Ohara
    Citation: Inflammation and Regeneration 2021 41:19
    Content type: Review Published on:

  13. Systemic sclerosis (SSc) is a complex disease, in which an interaction of genetic and environmental factors plays an important role in its development and pathogenesis. A number of genetic studies, including c...

    Authors: Yuko Ota and Masataka Kuwana
    Citation: Inflammation and Regeneration 2021 41:17
    Content type: Review Published on:

  14. Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...

    Authors: Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono and Yoshiya Ito
    Citation: Inflammation and Regeneration 2021 41:16
    Content type: Review Published on:

  17. Silicone tube (ST) conduits have been accepted as a therapeutic alternative to direct nerve suturing in the treatment of nerve injuries; however, the search for optimal adjuncts to maximize the outcomes is sti...

    Authors: Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari and Alireza Shams
    Citation: Inflammation and Regeneration 2021 41:13
    Content type: Research article Published on:

  18. Extracellular vesicles (EVs) are known to be secreted by various cells. In particular, mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have tissue repair capacity and anti-inflammatory properties. Dental pul...

    Authors: Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara and Jun Takebe
    Citation: Inflammation and Regeneration 2021 41:12
    Content type: Research article Published on:

  19. The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and...

    Authors: Masahiro Nakano, Yukiko Iwasaki and Keishi Fujio
    Citation: Inflammation and Regeneration 2021 41:11
    Content type: Review Published on:

  24. To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...

    Authors: Yuya Shirai and Yukinori Okada
    Citation: Inflammation and Regeneration 2021 41:6
    Content type: Review Published on:

  25. Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and re...

    Authors: Azela Glady, Arno Vandebroek and Masato Yasui
    Citation: Inflammation and Regeneration 2021 41:4
    Content type: Research article Published on:

  26. Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...

    Authors: Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2021 41:5
    Content type: Review Published on:

  27. The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be genetic, but secondary to rapidly modernized environmen...

    Authors: Yusuke Yoshimatsu, Yohei Mikami and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:3
    Content type: Review Published on:

  29. Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiat...

    Authors: Erinn Zixuan Sim, Nobuaki Shiraki and Shoen Kume
    Citation: Inflammation and Regeneration 2021 41:1
    Content type: Review Published on:

  31. The world today is facing a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which mainly causes a respiratory disease known as coronavirus disease 2019 (COVID-19). Therefore, i...

    Authors: Taichiro Minami, Yasunori Iwata and Takashi Wada
    Citation: Inflammation and Regeneration 2020 40:31
    Content type: Review Published on:

    The Correction to this article has been published in Inflammation and Regeneration 2021 41:24

  32. Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of t...

    Authors: Kento Otani and Takashi Shichita
    Citation: Inflammation and Regeneration 2020 40:28
    Content type: Review Published on:

  33. Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunte...

    Authors: Sou Nakamura, Naoshi Sugimoto and Koji Eto
    Citation: Inflammation and Regeneration 2020 40:30
    Content type: Review Published on:

  34. The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are s...

    Authors: Arun Kumar Rajendan, Yoshinori Arisaka, Nobuhiko Yui and Sachiko Iseki
    Citation: Inflammation and Regeneration 2020 40:27
    Content type: Review Published on:

  36. Bone homeostasis is dynamically regulated by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Visualizing and evaluating the dynamics of bone cells in vivo remain difficult u...

    Authors: Kunihiko Hashimoto, Takashi Kaito, Junichi Kikuta and Masaru Ishii
    Citation: Inflammation and Regeneration 2020 40:26
    Content type: Review Published on:

  37. Spinal cord injury (SCI) is a devastating event that causes permanent neurologic impairments. Cell transplantation therapy using neural precursor cells (NPCs) is a promising intervention aiming to replace dama...

    Authors: Narihito Nagoshi, Hideyuki Okano and Masaya Nakamura
    Citation: Inflammation and Regeneration 2020 40:40
    Content type: Review Published on:

  38. Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been ...

    Authors: Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi, Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2020 40:25
    Content type: Research article Published on:

  40. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread globally to most countries. In Japan, the first COVID-...

    Authors: Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe and Hirotaka Kanuka
    Citation: Inflammation and Regeneration 2020 40:38
    Content type: Review Published on:

  41. In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world d...

    Authors: Misato Hashizume
    Citation: Inflammation and Regeneration 2020 40:24
    Content type: Review Published on:

  42. The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some...

    Authors: Shintaro Hojyo, Mona Uchida, Kumiko Tanaka, Rie Hasebe, Yuki Tanaka, Masaaki Murakami and Toshio Hirano
    Citation: Inflammation and Regeneration 2020 40:37
    Content type: Review Published on:

  45. Hair follicle (HF) formation and growth are sustained by epithelial-mesenchymal interaction via growth factors and cytokines. Pivotal roles of FGFs on HF regeneration and neogenesis have been reported mainly i...

    Authors: Misaki Kinoshita-Ise, Aki Tsukashima, Tomonari Kinoshita, Yoshimi Yamazaki and Manabu Ohyama
    Citation: Inflammation and Regeneration 2020 40:35
    Content type: Research article Published on:

  46. In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are ...

    Authors: Kiyotaka Okada, Minoru Nishioka and Hiroshi Kaji
    Citation: Inflammation and Regeneration 2020 40:22
    Content type: Review Published on:

  47. The COVID-19 pandemic highlighted the vulnerability of every aspect of the globalized world, including R&D. Potentially critical R&D areas have been neglected because of the lack of market-driven incentives. H...

    Authors: Hiroki Nakatani, Kei Katsuno and Hayato Urabe
    Citation: Inflammation and Regeneration 2020 40:34
    Content type: Review Published on:

  48. Due to the nature of enhanced resistance to conventional chemo/radiotherapies and metastasis, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for cancer eradication. To tac...

    Authors: Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2020 40:33
    Content type: Review Published on:

  49. It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mech...

    Authors: Yoshitaka Kase and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:32
    Content type: Rapid communication Published on:

  50. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinica...

    Authors: Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2020 40:20
    Content type: Review Published on:


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Inflammation and Regeneration

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