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  1. The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that prevents systemic autoimmune diseases and inhibits inflammation by encount...

    Authors: Yosuke Harada, Kentaro Miyamoto, Akihiko Chida, Anna Tojo Okuzawa, Yusuke Yoshimatsu, Yumi Kudo and Tomohisa Sujino
    Citation: Inflammation and Regeneration 2022 42:47
  2. Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the r...

    Authors: Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Anh Phuong Nguyen, Naoaki Ohkubo, Shigeru Iwata, Shigeaki Kato and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2022 42:46

    The Correction to this article has been published in Inflammation and Regeneration 2022 42:57

  3. The microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site fo...

    Authors: Takeshi Nitta
    Citation: Inflammation and Regeneration 2022 42:33
  4. Multiple sclerosis (MS) is a progressive autoimmune demyelinating disease of the central nervous system. To date, there is no effective therapy for it. Our study aimed to determine the potential role of platel...

    Authors: Mariam F. Farid, Yara S. Abouelela, Noha A. E. Yasin, Mohamed R. Mousa, Marwa A. Ibrahim, Abdelbary Prince and Hamdy Rizk
    Citation: Inflammation and Regeneration 2022 42:45
  5. Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable ...

    Authors: Khatereh Khorsandi, Reza Hosseinzadeh, HomaSadat Esfahani, Kavosh Zandsalimi, Fedora Khatibi Shahidi and Heidi Abrahamse
    Citation: Inflammation and Regeneration 2022 42:40
  6. Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. Characterized by the loss of learning, memory, problem-solving, language, and other thinking abilit...

    Authors: Chongyun Wu, Luoman Yang, Shu Feng, Ling Zhu, Luodan Yang, Timon Cheng-Yi Liu and Rui Duan
    Citation: Inflammation and Regeneration 2022 42:31
  7. Rapidly expanding clones (RECs) are one of the single-cell-derived mesenchymal stem cell clones sorted from human bone marrow mononuclear cells (BMMCs), which possess advantageous features. The RECs exhibit lo...

    Authors: Takashi Suyama, Yuto Takemoto, Hiromi Miyauchi, Yuko Kato, Yumi Matsuzaki and Ryuji Kato
    Citation: Inflammation and Regeneration 2022 42:30
  8. Inflammatory response is an important characteristic affecting prognosis and therapeutic response in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory response are still under exp...

    Authors: Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong and Jiade J. Lu
    Citation: Inflammation and Regeneration 2022 42:29
  9. Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in p...

    Authors: Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li, Xu-Yang Hu, Xing-Yu You, Shui-Sheng Yu, Zi-Yu Li, Lei Chen, Da-Sheng Tian, Mei-Ge Zheng, Li Cheng and Jue-Hua Jing
    Citation: Inflammation and Regeneration 2022 42:44
  10. Highly regulated gene expression program underlies osteogenesis of mesenchymal stem cells (MSCs), but the regulators in the program are not entirely identified. As enhancer RNAs (eRNAs) have recently emerged a...

    Authors: Anh Phuong Nguyen, Kaoru Yamagata, Shigeru Iwata, Gulzhan Trimova, Tong Zhang, Yu Shan, Mai-Phuong Nguyen, Koshiro Sonomoto, Shingo Nakayamada, Shigeaki Kato and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2022 42:43
  11. Helicobacter pylori (HP) is a Gram-negative bacterium that colonizes the human stomach chronically. Colonization of HP in the gastric mucosa not only causes gastrointestinal diseases, but also is associated with ...

    Authors: Ah-Mee Park and Ikuo Tsunoda
    Citation: Inflammation and Regeneration 2022 42:39
  12. During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and me...

    Authors: Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue and Tetsuro Watabe
    Citation: Inflammation and Regeneration 2022 42:38
  13. Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasi...

    Authors: Masayuki Tsukasaki and Hiroshi Takayanagi
    Citation: Inflammation and Regeneration 2022 42:27
  14. NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extrace...

    Authors: Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin…
    Citation: Inflammation and Regeneration 2022 42:25
  15. Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP...

    Authors: Yang Mu, Tai-lang Yin, Yan Zhang, Jing Yang and Yan-ting Wu
    Citation: Inflammation and Regeneration 2022 42:24
  16. Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory “seed-and-soil.” Both cancer cell-intrinsic properties (“seed”) and fertile microenvironment ...

    Authors: Atsuko Deguchi and Yoshiro Maru
    Citation: Inflammation and Regeneration 2022 42:22
  17. Among the different etiologies for fever of unknown origin in children, infectious diseases are the most frequent final diagnosis, followed by autoimmune diseases and malignancies. Autoinflammatory diseases ar...

    Authors: Akihiro Yachie
    Citation: Inflammation and Regeneration 2022 42:21
  18. Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particula...

    Authors: Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe and Hideyuki Okano
    Citation: Inflammation and Regeneration 2022 42:20
  19. Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and c...

    Authors: Yoshimasa Tanaka, Megumi Nishikawa, Kaho Kamisaki, Saki Hachiya, Moeka Nakamura, Takahiro Kuwazuru, Susumu Tanimura, Kiyoshi Soyano and Kohsuke Takeda
    Citation: Inflammation and Regeneration 2022 42:18
  20. Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts. An advanced intravital imaging system using a two-photon...

    Authors: Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta and Masaru Ishii
    Citation: Inflammation and Regeneration 2022 42:17
  21. The duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA positivity will be important to prevent the spread of coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis...

    Authors: Yasutaka Okita, Takayoshi Morita and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2022 42:16
  22. Neuropathic pain is often chronic and can persist after overt tissue damage heals, suggesting that its underlying mechanism involves the alteration of neuronal function. Such an alteration can be a direct cons...

    Authors: Shin-ichiro Hiraga, Takahide Itokazu, Mariko Nishibe and Toshihide Yamashita
    Citation: Inflammation and Regeneration 2022 42:15
  23. The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signal...

    Authors: Taku Saito
    Citation: Inflammation and Regeneration 2022 42:14
  24. Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue is the origin of chronic inflammation of metabolic syndrome...

    Authors: Rumi Hachiya, Miyako Tanaka, Michiko Itoh and Takayoshi Suganami
    Citation: Inflammation and Regeneration 2022 42:13
  25. Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly patients.

    Authors: Salwa Suliman, Anna Mieszkowska, Justyna Folkert, Neha Rana, Samih Mohamed-Ahmed, Tiziana Fuoco, Anna Finne-Wistrand, Kai Dirscherl, Bodil Jørgensen, Kamal Mustafa and Katarzyna Gurzawska-Comis
    Citation: Inflammation and Regeneration 2022 42:12
  26. Systemic lupus erythematosus (SLE), an autoimmune disorder that damages various organ systems, is caused by a combination of genetic and environmental factors. Although germline mutations of several genes are ...

    Authors: Sze-Ming Law, Shuji Akizuki, Akio Morinobu and Koichiro Ohmura
    Citation: Inflammation and Regeneration 2022 42:10
  27. Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in...

    Authors: Lili Quan, Akiko Uyeda and Rieko Muramatsu
    Citation: Inflammation and Regeneration 2022 42:7
  28. The expression of FZD5 distinguishes immature human mesenchymal stem/stromal cells (MSC) in cultures, and the function of FZD5 is crucial for maintaining the proliferation and multilineage differentiation capacit...

    Authors: Satoru Miyagi, Yuko Kato, Ayako Watanabe, Kenichi Miyamoto, Rintaro Yoshikawa, Keita Hagiya, Daisuke Hirano and Yumi Matsuzaki
    Citation: Inflammation and Regeneration 2022 42:6
  29. Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens. To suppress allo-immune respons...

    Authors: Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2022 42:4
  30. ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO...

    Authors: Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa and Shuji Terai
    Citation: Inflammation and Regeneration 2022 42:3
  31. Within the extensively developed therapeutic application of mesenchymal stem cells (MSCs), allogenic immunomodulatory therapy is among the promising categories. Although donor selection is a critical early pro...

    Authors: Yuta Imai, Kei Kanie and Ryuji Kato
    Citation: Inflammation and Regeneration 2022 42:8
  32. The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of t...

    Authors: Yoshimitsu Nakanishi, Sujin Kang and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2022 42:5
  33. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investi...

    Authors: Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato and Takafumi Ichikawa
    Citation: Inflammation and Regeneration 2022 42:1
  34. Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel...

    Authors: Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe and Fumiko Itoh
    Citation: Inflammation and Regeneration 2021 41:35
  35. Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS ...

    Authors: Kenichi Serizawa, Haruna Tomizawa-Shinohara, Shota Miyake, Kenji Yogo and Yoshihiro Matsumoto
    Citation: Inflammation and Regeneration 2021 41:34
  36. The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan of more than 37 years and shows a negligible senescence phenotype, suggesting that tissue stem cells of NMRs are highly capable of m...

    Authors: Yuki Yamamura, Yoshimi Kawamura, Yuki Oiwa, Kaori Oka, Nobuyuki Onishi, Hideyuki Saya and Kyoko Miura
    Citation: Inflammation and Regeneration 2021 41:31
  37. The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of vario...

    Authors: Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata and Naoe Kaneko
    Citation: Inflammation and Regeneration 2021 41:33
  38. Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in ...

    Authors: Masayuki Miyasaka
    Citation: Inflammation and Regeneration 2021 41:32

The official journal of the Japanese Society of Inflammation and Regeneration.

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